9B36

Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.

9B36 の概要

• エントリーDOI: 10.2210/pdb9b36/pdb
• EMDBエントリー: 44129
• 分子名称: Glutamate receptor ionotropic, kainate 2, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, ... (15 entities in total)
• 機能のキーワード: kainate receptor, gluk2, positive allosteric modulator, bpam344, open, concanavalin a, cona, glutamate, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 549861.95

構造登録者

Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (登録日: 2024-03-18, 公開日: 2024-05-22, 最終更新日: 2024-06-26)

• 主引用文献: Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I.; Kainate receptor channel opening and gating mechanism.; Nature, 630:762-768, 2024; PubMed: 38778115; DOI: 10.1038/s41586-024-07475-0

実験手法

ELECTRON MICROSCOPY (4.29 Å)