9AYQ

SMARCA2 in complex with a pyridine-2-one-based inhibitor

This is a non-PDB format compatible entry.

Summary for 9AYQ

• Entry DOI: 10.2210/pdb9ayq/pdb
• Descriptor: Probable global transcription activator SNF2L2, ADENOSINE-5'-DIPHOSPHATE, 4-cyano-N-[1-(2,2-difluoroethyl)-5-fluoro-6-oxo-1,6-dihydropyridin-3-yl]-5-(trifluoromethyl)thiophene-2-carboxamide, ... (4 entities in total)
• Functional Keywords: helicase, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 163416.27

Authors

Farrow, N.A.,Cocozaki, A. (deposition date: 2024-03-08, release date: 2025-04-09)

• Primary citation: Alford, J.,Farrow, N.A.; Discovery of a SMARCA2/4 ATPase Inhibitors Suitable for Use in SMARCA4-mutant Preclinical Models; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.9 Å)