9AYQ
SMARCA2 in complex with a pyridine-2-one-based inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Probable global transcription activator SNF2L2 | polymer | 693 | 80885.7 | 2 | UniProt (P51531) Pfam (PF00176) Pfam (PF00271) Pfam (PF14619) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | C, E (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 3 | D, F (A, B) | 4-cyano-N-[1-(2,2-difluoroethyl)-5-fluoro-6-oxo-1,6-dihydropyridin-3-yl]-5-(trifluoromethyl)thiophene-2-carboxamide | non-polymer | 395.3 | 2 | Chemie (A1AHQ) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 495 - 693 (UniProt: P51531)
A, B: 701 - 1157 (UniProt: P51531)
A, B: 1166 - 1302 (UniProt: P51531)
| PDB | External Database | Details |
|---|---|---|
| Met 469 | - | initiating methionine |
| Ser 470 | - | expression tag |
| Tyr 471 | - | expression tag |
| Tyr 472 | - | expression tag |
| His 473 | - | expression tag |
| His 474 | - | expression tag |
| His 475 | - | expression tag |
| His 476 | - | expression tag |
| His 477 | - | expression tag |
| His 478 | - | expression tag |
| Asp 479 | - | expression tag |
| Tyr 480 | - | expression tag |
| Asp 481 | - | expression tag |
| Ile 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Thr 484 | - | expression tag |
| Thr 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Asn 487 | - | expression tag |
| Leu 488 | - | expression tag |
| Tyr 489 | - | expression tag |
| Phe 490 | - | expression tag |
| Gln 491 | - | expression tag |
| Ser 492 | - | expression tag |
| Ile 493 | - | expression tag |
| Ala 494 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 694 | - | linker |
| Ala 695 | - | linker |
| Ser 696 | - | linker |
| Gly 697 | - | linker |
| Gly 698 | - | linker |
| Ser 699 | - | linker |
| Gly 700 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 1158 | - | linker |
| Gly 1159 | - | linker |
| Gly 1160 | - | linker |
| Ser 1161 | - | linker |
| Gly 1162 | - | linker |
| Gly 1163 | - | linker |
| Ser 1164 | - | linker |
| Gly 1165 | - | linker |
| Asp 1303 | - | expression tag |
| Tyr 1304 | - | expression tag |
| Lys 1305 | - | expression tag |
| Asp 1306 | - | expression tag |
| Asp 1307 | - | expression tag |
| Asp 1308 | - | expression tag |
| Asp 1309 | - | expression tag |
| Lys 1310 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 161771.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1645.0 | |
| All* | Total formula weight | 163416.3 |
