9AY9

Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor

This is a non-PDB format compatible entry.

Summary for 9AY9

• Entry DOI: 10.2210/pdb9ay9/pdb
• Descriptor: Protein arginine N-methyltransferase 9, 7-[5-S-(4-{[(2-tert-butylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: methyltransferase, prmt9, sgc, transport protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 324003.92

Authors

Zeng, H.,Dong, A.,Li, Y.,Hutchinson, A.,Seitova, A.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2024-03-07, release date: 2024-12-04)

• Primary citation: Zeng, H.,Dong, A.,Li, Y.,Hutchinson, A.,Seitova, A.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)