9EZJ

Apo human TDO in complex with a bound inhibitor (Cpd-4)

This is a non-PDB format compatible entry.

Summary for 9EZJ

• Entry DOI: 10.2210/pdb9ezj/pdb
• Descriptor: Tryptophan 2,3-dioxygenase, alpha-methyl-L-tryptophan, ethyl (9~{R})-2-methoxy-4-oxidanylidene-9-[[(1~{S})-1-phenylethyl]-[(2-propan-2-ylphenyl)carbamoyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-3-carboxylate, ... (4 entities in total)
• Functional Keywords: apo-tdo, heme, inhibitor, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 193992.05

Authors

Wicki, M.,Mac Sweeney, A. (deposition date: 2024-04-12, release date: 2024-06-05)

• Primary citation: Lotz-Jenne, C.,lange, R.,Cren, S.,Bourquin, G.,Goglia, L.,Kimmerlin, T.,Wicki, M.,Mueller, M.,Artico, N.,Ackerknecht, S.,Joesch, C.,Mac Sweeney, A.; Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.612 Å)