9EZJ

Apo human TDO in complex with a bound inhibitor (Cpd-4)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006568	biological_process	tryptophan metabolic process
A	0006569	biological_process	tryptophan catabolic process
A	0016597	molecular_function	amino acid binding
A	0019441	biological_process	tryptophan catabolic process to kynurenine
A	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051289	biological_process	protein homotetramerization
A	1904842	biological_process	response to nitroglycerin
B	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006568	biological_process	tryptophan metabolic process
B	0006569	biological_process	tryptophan catabolic process
B	0016597	molecular_function	amino acid binding
B	0019441	biological_process	tryptophan catabolic process to kynurenine
B	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0051289	biological_process	protein homotetramerization
B	1904842	biological_process	response to nitroglycerin
C	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006568	biological_process	tryptophan metabolic process
C	0006569	biological_process	tryptophan catabolic process
C	0016597	molecular_function	amino acid binding
C	0019441	biological_process	tryptophan catabolic process to kynurenine
C	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0051289	biological_process	protein homotetramerization
C	1904842	biological_process	response to nitroglycerin
D	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006568	biological_process	tryptophan metabolic process
D	0006569	biological_process	tryptophan catabolic process
D	0016597	molecular_function	amino acid binding
D	0019441	biological_process	tryptophan catabolic process to kynurenine
D	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	0051289	biological_process	protein homotetramerization
D	1904842	biological_process	response to nitroglycerin

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
A	PHE72
D	PHE72
D	ARG144
D	THR342
A	ARG144
A	THR342
B	PHE72
B	ARG144
B	THR342
C	PHE72
C	ARG144
C	THR342

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
A	HIS328
B	HIS328
C	HIS328
D	HIS328

---