8ZLO

F0502B-bound E46K alpha-synuclein fibril

Summary for 8ZLO

• Entry DOI: 10.2210/pdb8zlo/pdb
• EMDB information: 60231
• Descriptor: Alpha-synuclein, 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol (2 entities in total)
• Functional Keywords: amyloid fibril, complex, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 69479.67

Authors

Liu, K.E.,Tao, Y.Q.,Li, D.,Liu, C. (deposition date: 2024-05-20, release date: 2024-09-11)

• Primary citation: Liu, K.,Tao, Y.,Zhao, Q.,Xia, W.,Li, X.,Zhang, S.,Yao, Y.,Xiang, H.,Han, C.,Tan, L.,Sun, B.,Li, D.,Li, A.,Liu, C.; Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.; Proc.Natl.Acad.Sci.USA, 121:e2321633121-e2321633121, 2024; PubMed: 39172784; DOI: 10.1073/pnas.2321633121

Experimental method

ELECTRON MICROSCOPY (3.1 Å)