8ZLO

F0502B-bound E46K alpha-synuclein fibril

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Alpha-synuclein	polymer	55	5402.2	12	UniProt (P37840) Pfam (PF01387)	Homo sapiens (human)	Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,NACP
2	M, N, O, P, Q... (E, F, G, H, I...)	2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol	non-polymer		465.4	10	Chemie (1KI)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, O, T: 45 - 99 (UniProt: P37840)

PDB	External Database	Details
Lys 46	Glu 46	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	64825.9
Non-Polymers*	Number of molecules	10
	Total formula weight	4653.8
All*	Total formula weight	69479.7

*Water molecules are not included.