8ZEU

CryoEM structure of GR2002-F(ab')2: TSLP complex

Summary for 8ZEU

• Entry DOI: 10.2210/pdb8zeu/pdb
• EMDB information: 60046
• Descriptor: Fab-H1A10 fragment, heavy chain, Fab fragment, light chain, Thymic stromal lymphopoietin, ... (4 entities in total)
• Functional Keywords: cryo-em, tslp-f(ab')2 complex, bispecific antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 234713.00

Authors

Zhigang, L.,Junjie, H. (deposition date: 2024-05-07, release date: 2025-05-28, Last modification date: 2025-12-10)

• Primary citation: Zhang, X.,Luo, S.,Hao, X.,Liu, Y.,Hu, J.,Yang, J.,Qin, H.,Liu, Z.; Preclinical Development of GR2002, a Novel Anti-TSLP Bispecific Antibody With Potent TSLP Inhibitory Effects.; Allergy, 80:2077-2080, 2025; PubMed: 40372096; DOI: 10.1111/all.16591

Experimental method

ELECTRON MICROSCOPY (3.39 Å)