8ZEU

CryoEM structure of GR2002-F(ab')2: TSLP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001961	biological_process	positive regulation of cytokine-mediated signaling pathway
C	0005125	molecular_function	cytokine activity
C	0005139	molecular_function	interleukin-7 receptor binding
C	0005576	cellular_component	extracellular region
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008284	biological_process	positive regulation of cell population proliferation
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0032722	biological_process	positive regulation of chemokine production
C	0032733	biological_process	positive regulation of interleukin-10 production
C	0032736	biological_process	positive regulation of interleukin-13 production
C	0032754	biological_process	positive regulation of interleukin-5 production
C	0032755	biological_process	positive regulation of interleukin-6 production
C	0033005	biological_process	positive regulation of mast cell activation
C	0038111	biological_process	interleukin-7-mediated signaling pathway
C	0043066	biological_process	negative regulation of apoptotic process
C	0050729	biological_process	positive regulation of inflammatory response
C	0071654	biological_process	positive regulation of chemokine (C-C motif) ligand 1 production
C	0071657	biological_process	positive regulation of granulocyte colony-stimulating factor production
C	1904894	biological_process	positive regulation of receptor signaling pathway via STAT
G	0001961	biological_process	positive regulation of cytokine-mediated signaling pathway
G	0005125	molecular_function	cytokine activity
G	0005139	molecular_function	interleukin-7 receptor binding
G	0005576	cellular_component	extracellular region
G	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
G	0008284	biological_process	positive regulation of cell population proliferation
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0032722	biological_process	positive regulation of chemokine production
G	0032733	biological_process	positive regulation of interleukin-10 production
G	0032736	biological_process	positive regulation of interleukin-13 production
G	0032754	biological_process	positive regulation of interleukin-5 production
G	0032755	biological_process	positive regulation of interleukin-6 production
G	0033005	biological_process	positive regulation of mast cell activation
G	0038111	biological_process	interleukin-7-mediated signaling pathway
G	0043066	biological_process	negative regulation of apoptotic process
G	0050729	biological_process	positive regulation of inflammatory response
G	0071654	biological_process	positive regulation of chemokine (C-C motif) ligand 1 production
G	0071657	biological_process	positive regulation of granulocyte colony-stimulating factor production
G	1904894	biological_process	positive regulation of receptor signaling pathway via STAT

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR193-HIS199
A	TYR197-HIS203
H	TYR202-HIS208

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