8ZCL

Ambient Temperature Crystal Structure of Fc Fragment of Human IgG1 from Biosimilar VEGF-Trap

Summary for 8ZCL

• Entry DOI: 10.2210/pdb8zcl/pdb
• Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: fusion protein, immunoglobin, n-glycans, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 50155.00

Authors

Destan, E.,DeMirci, H. (deposition date: 2024-04-30, release date: 2024-05-08, Last modification date: 2025-05-21)

• Primary citation: Destan, E.,Turkut, E.,Aldeniz, A.,Kang, J.,Tosha, T.,Yabashi, M.,Yilmaz, B.,Timucin, C.,Matsuura, H.,Kawano, Y.,Cinkaya, I.,Demirci, H.; Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF-Trap; Small Struct, 2025; DOI: 10.1002/sstr.202400680

Experimental method

X-RAY DIFFRACTION (2.6 Å)