8YX1

CD40 in complex with Bleselumab Fab

Summary for 8YX1

Entry DOI	10.2210/pdb8yx1/pdb
Descriptor	Bleselumab, heavy chain, Bleselumab, light chain, Tumor necrosis factor receptor superfamily member 5, ... (4 entities in total)
Functional Keywords	cd40, dacetuzumab, bleselumab, agonist activity, tumor necrosis factor, immune system
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	134944.52
Authors	Caaveiro, J.M.M.,Fernandez-Perez, J.,Tsumoto, K. (deposition date: 2024-04-01, release date: 2024-05-08, Last modification date: 2024-05-22)
Primary citation	Asano, R.,Nakakido, M.,Perez, J.F.,Ise, T.,Caaveiro, J.M.M.,Nagata, S.,Tsumoto, K. Crystal structures of human CD40 in complex with monoclonal antibodies dacetuzumab and bleselumab. Biochem.Biophys.Res.Commun., 714:149969-149969, 2024 Cited by PubMed: 38657446 DOI: 10.1016/j.bbrc.2024.149969 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation