8YQD

Crystal structure of human transthyretin variant A97S in complex with Tafamidis

Summary for 8YQD

Entry DOI	10.2210/pdb8yqd/pdb
Descriptor	Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid (3 entities in total)
Functional Keywords	transport thyroxine, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	27492.14
Authors	Tzeng, S.R.,Huang, C.H.,Wang, Y.S.,Hsieh, M.F. (deposition date: 2024-03-19, release date: 2025-01-29)
Primary citation	Chao, C.C.,Tzeng, S.R.,Chiang, M.C.,Hsueh, H.W.,Hsieh, W.J.,Chao, Y.C.,Cheng, M.F.,Lin, Y.H.,Su, M.Y.,Huang, C.H.,Wang, Y.S.,Hsieh, M.F.,Tseng, P.H.,Hsieh, S.T. Diflunisal versus tafamidis on neuropathy and cardiomyopathy in hereditary transthyretin amyloidosis. Ann Clin Transl Neurol, 11:2426-2438, 2024 Cited by PubMed Abstract: Hereditary transthyretin (TTR) amyloidosis (ATTRv) is frequently complicated by polyneuropathy (ATTRv-PN) and cardiomyopathy (ATTRv-CM). The long-term efficacy of diflunisal on both polyneuropathy and cardiomyopathy in ATTRv patients, especially those with non-V30M genotypes, has not been fully investigated and compared with that of tafamidis. PubMed: 39096004 DOI: 10.1002/acn3.52158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation