8YGQ

Crystal structure of Human TEAD2 in complex with Cobimetinib

Summary for 8YGQ

• Entry DOI: 10.2210/pdb8ygq/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, PALMITIC ACID, [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE (3 entities in total)
• Functional Keywords: hippo pathway, tead inhibitor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 52246.11

Authors

He, X.J.,Hu, L.Q.,Wu, M.Y. (deposition date: 2024-02-26, release date: 2025-03-05)

• Primary citation: He, X.J.,Hu, L.Q.,Wu, M.Y.; Crystal structure of Human TEAD2 in complex with Cobimetinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.71 Å)