8YD1

CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1

Summary for 8YD1

• Entry DOI: 10.2210/pdb8yd1/pdb
• EMDB information: 39162
• Descriptor: ATP-dependent Clp protease ATP-binding subunit ClpC1, ATP-dependent Clp protease proteolytic subunit 2, ATP-dependent Clp protease proteolytic subunit 1, ... (8 entities in total)
• Functional Keywords: mycobacterium tuberculosis, caseinolytic protease system, activation, hydrolase
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 21
• Total formula weight: 727396.93

Authors

Zhou, B.,Zhao, H.,Gao, Y.,Chen, X.,Zhang, T.,He, J.,Xiong, X. (deposition date: 2024-02-19, release date: 2025-03-19)

• Primary citation: Zhou, B.,Zhao, H.,Gao, Y.,Chen, X.,Zhang, T.,He, J.,Xiong, X.; Activation mechanism of caseinolytic chaperone-protease system in Mycobacterium tuberculosis by the anti-cancer drug bortezomib; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.81 Å)