8YD1
CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease ATP-binding subunit ClpC1 | polymer | 657 | 73270.3 | 6 | UniProt (P9WPC9) Pfam (PF00004) Pfam (PF17871) Pfam (PF07724) Pfam (PF10431) | Mycobacterium tuberculosis H37Rv | |
| 2 | G, H, I, J, K... (G, H, I, J, K...) | ATP-dependent Clp protease proteolytic subunit 2 | polymer | 181 | 19869.7 | 7 | UniProt (P9WPC3) Pfam (PF00574) | Mycobacterium tuberculosis H37Rv | Endopeptidase Clp 2 |
| 3 | N, O, P, Q, R... (N, O, P, Q, R...) | ATP-dependent Clp protease proteolytic subunit 1 | polymer | 178 | 19383.1 | 7 | UniProt (P9WPC5) Pfam (PF00574) | Mycobacterium tuberculosis H37Rv | Endopeptidase Clp 1 |
| 4 | U (a) | Beta-casein | polymer | 24 | 2624.3 | 1 | UniProt (P02666) | Bos grunniens (domestic yak) | |
| 5 | AA, EA, FA, IA, V... (B, C, D, A) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 6 | BA, CA, DA, GA, JA... (B, C, D, A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 7 | Chemie (ATP) | |||
| 7 | HA, KA, LA (D, E, F) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 8 | MA, NA, OA, PA, QA... (G, H, I, J, K...) | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | non-polymer | 384.2 | 14 | Chemie (BO2) |
Sequence modifications
A, B, C, D, E, F: 168 - 824 (UniProt: P9WPC9)
| PDB | External Database | Details |
|---|---|---|
| Ala 288 | Glu 288 | engineered mutation |
| Ser 444 | Phe 444 | engineered mutation |
| Ala 626 | Glu 626 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 717015.6 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 10381.3 | |
| All* | Total formula weight | 727396.9 |
