8Y6H
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
Summary for 8Y6H
Entry DOI | 10.2210/pdb8y6h/pdb |
EMDB information | 38986 |
Descriptor | ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab light chain, UIC2 Fab heavy chain, ... (4 entities in total) |
Functional Keywords | abc transporter, elacridar, p-glycoprotein, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 220929.06 |
Authors | Hamaguchi-Suzuki, N.,Adachi, N.,Moriya, T.,Kawasaki, M.,Suzuki, K.,Anzai, N.,Senda, T.,Murata, T. (deposition date: 2024-02-02, release date: 2024-04-17) |
Primary citation | Hamaguchi-Suzuki, N.,Adachi, N.,Moriya, T.,Yasuda, S.,Kawasaki, M.,Suzuki, K.,Ogasawara, S.,Anzai, N.,Senda, T.,Murata, T. Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules. Biochem.Biophys.Res.Commun., 709:149855-149855, 2024 Cited by PubMed: 38579618DOI: 10.1016/j.bbrc.2024.149855 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.49 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)