8XQ0

Crystal structure of spleen tyrosine kinase(SYK)in complex with SKI-G-1653

This is a non-PDB format compatible entry.

Summary for 8XQ0

• Entry DOI: 10.2210/pdb8xq0/pdb
• Descriptor: Tyrosine-protein kinase SYK, cyclopropyl-[5-[[4-[4-[[(3~{S},4~{S})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-indol-3-yl]methanone (3 entities in total)
• Functional Keywords: tyrosine kinase, phosphotyrosines, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 137610.18

Authors

Bong, S.M.,Lee, B.I. (deposition date: 2024-01-04, release date: 2025-01-15)

• Primary citation: Lee, B.I.; Crystal structure of spleen tyrosine kinase(SYK) in complex with SKI-G-1673; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)