8XQ0

Crystal structure of spleen tyrosine kinase(SYK)in complex with SKI-G-1653

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Tyrosine-protein kinase SYK	polymer	290	33901.0	4	UniProt (P43405) Pfam (PF07714)	Homo sapiens (human)	Spleen tyrosine kinase,p72-Syk
2	E, F, G, H (A, B, C, D)	cyclopropyl-[5-[[4-[4-[[(3~{S},4~{S})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-indol-3-yl]methanone	non-polymer		501.6	4	Chemie (A1LV4)
3	I, J, K, L (A, B, C, D)	water	water		18.0	205	Chemie (HOH)

Sequence modifications

A, B, C, D: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Leu 636	-	expression tag
Glu 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	135603.9
Non-Polymers*	Number of molecules	4
	Total formula weight	2006.3
All*	Total formula weight	137610.2

*Water molecules are not included.