8XOM

Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE

Summary for 8XOM

• Entry DOI: 10.2210/pdb8xom/pdb
• EMDB information: 38534
• Descriptor: ATP-binding cassette sub-family C member 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, METHOTREXATE, ... (6 entities in total)
• Functional Keywords: abc transporter mrp, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 158169.81

Authors

Zhang, P.F.,Liu, Z. (deposition date: 2024-01-01, release date: 2024-07-17)

• Primary citation: Zhu, Y.,Xing, X.,Wang, F.,Chen, L.,Zhong, C.,Lu, X.,Yu, Z.,Yang, Y.,Yao, Y.,Song, Q.,Han, S.,Liu, Z.,Zhang, P.; The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport.; Febs Lett., 2024; PubMed: 38886124; DOI: 10.1002/1873-3468.14955

Experimental method

ELECTRON MICROSCOPY (3.05 Å)