8XOM
Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ATP-binding cassette sub-family C member 4 | polymer | 1325 | 149693.9 | 1 | UniProt (O15439) Pfam (PF00664) Pfam (PF00005) | Homo sapiens (human) | MRP/cMOAT-related ABC transporter,Multi-specific organic anion transporter B,MOAT-B,Multidrug resistance-associated protein 4 |
| 2 | B (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | C (A) | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
| 4 | D, E, F, G, H... (A) | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol | non-polymer | 516.8 | 14 | Chemie (DU0) | |||
| 5 | R (A) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) | |||
| 6 | S (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 149693.9 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 8475.9 | |
| All* | Total formula weight | 158169.8 |
