8XKP

Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 17c

This is a non-PDB format compatible entry.

Summary for 8XKP

• Entry DOI: 10.2210/pdb8xkp/pdb
• Descriptor: Tyrosine-protein kinase Fes/Fps, SULFATE ION, 7-[[(1R,2S)-2-azanylcyclohexyl]amino]-5-[[3-[(2S,6R)-2,6-dimethylmorpholin-4-yl]phenyl]amino]-4-oxidanylidene-3H-pyrido[3,4-d]pyridazine-8-carbonitrile, ... (4 entities in total)
• Functional Keywords: fes, c-fes, tyrosine protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43165.36

Authors

Baba, D.,Hanzawa, H. (deposition date: 2023-12-23, release date: 2025-01-01)

• Primary citation: Taniguchi, T.,Yasumatsu, I.,Inagaki, H.,Baba, D.,Toyota, A.,Kaneta, Y.,Odagiri, T.,Momose, T.,Kawai, J.,Imaoka, T.,Nakayama, K.; Optimization of novel pyrido-pyridazinone derivatives as FER tyrosine kinase inhibitor to lead to the clinical candidate (highly potent compound) DS08701581; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)