8XKP
Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 17c
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Fes/Fps | polymer | 375 | 42484.7 | 1 | UniProt (P07332) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | Feline sarcoma/Fujinami avian sarcoma oncogene homolog,Proto-oncogene c-Fes,Proto-oncogene c-Fps,p93c-fes |
| 2 | B, C (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (A) | 7-[[(1R,2S)-2-azanylcyclohexyl]amino]-5-[[3-[(2S,6R)-2,6-dimethylmorpholin-4-yl]phenyl]amino]-4-oxidanylidene-3H-pyrido[3,4-d]pyridazine-8-carbonitrile | non-polymer | 488.6 | 1 | Chemie (A1LWS) | |||
| 4 | E (A) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: 449 - 822 (UniProt: P07332)
| PDB | External Database | Details |
|---|---|---|
| Gly 448 | - | expression tag |
| Glu 662 | Gln 662 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42484.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 680.7 | |
| All* | Total formula weight | 43165.4 |
