8XJ0
Crystal structure of AmFab mutant - P40C/E165C (Light chain), G10C/P210C(Heavy chain)
Summary for 8XJ0
| Entry DOI | 10.2210/pdb8xj0/pdb |
| Descriptor | Adalimumab Fab Light chain, Adalimumab Fab Heavy chain (2 entities in total) |
| Functional Keywords | antidoby, fab, adalimumab, interdomain disulfide bond, protein binding, immune system |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 8 |
| Total formula weight | 189844.02 |
| Authors | Senda, M.,Yoshikawa, M.,Nakamura, H.,Ohkuri, T.,Senda, T. (deposition date: 2023-12-20, release date: 2024-02-14) |
| Primary citation | Yoshikawa, M.,Senda, M.,Nakamura, H.,Oda-Ueda, N.,Ueda, T.,Senda, T.,Ohkuri, T. Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochem.Biophys.Res.Commun., 700:149592-149592, 2024 Cited by PubMed: 38295648DOI: 10.1016/j.bbrc.2024.149592 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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