8XFD
Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)
Summary for 8XFD
Entry DOI | 10.2210/pdb8xfd/pdb |
Descriptor | Isoform L-type of Pyruvate kinase PKLR, MAGNESIUM ION, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (5 entities in total) |
Functional Keywords | pyruvate kinase, allosteric activator, mitapivat, ag-348, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 236615.43 |
Authors | |
Primary citation | Han, X.,Sandalova, T.,Zhang, C.,Mardinoglu, A.,Achour, A.,Sun, R. High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348 Crystals, 2024 Cited by DOI: 10.3390/cryst14050441PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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