8XFD

Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)

8XFD の概要

• エントリーDOI: 10.2210/pdb8xfd/pdb
• 分子名称: Isoform L-type of Pyruvate kinase PKLR, MAGNESIUM ION, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (5 entities in total)
• 機能のキーワード: pyruvate kinase, allosteric activator, mitapivat, ag-348, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 236615.43

構造登録者

Sun, R.,Achour, A. (登録日: 2023-12-13, 公開日: 2024-05-15)

• 主引用文献: Han, X.,Sandalova, T.,Zhang, C.,Mardinoglu, A.,Achour, A.,Sun, R.; High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348; Crystals, 2024; DOI: 10.3390/cryst14050441

実験手法

X-RAY DIFFRACTION (2.1 Å)