8XBM

Structure of Cx43/GJA1 gap junction intercellular channel in complex with diC8-PIP2

Summary for 8XBM

• Entry DOI: 10.2210/pdb8xbm/pdb
• EMDB information: 38220 38221 38223
• Descriptor: Gap junction alpha-1 protein, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (2 entities in total)
• Functional Keywords: cx43 gap junction channel, pip2, cytoplasmic loop, opening, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 360455.44

Authors

Lee, H.J.,Oh, J.S.,Cha, H.J.,Lee, C.W.,Jang, H.S. (deposition date: 2023-12-06, release date: 2025-06-11, Last modification date: 2026-02-25)

• Primary citation: Lee, H.J.,Cha, H.J.,Woo, J.S.; PIP2-dependent conformational changes and stabilization of cytoplasmic loop in Cx43/GJA1 gap junction channel; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)