8X7G

Crystal structure of the ternary complex of GID4-PROTAC(NEP108)-BRD4(BD1).

Summary for 8X7G

• Entry DOI: 10.2210/pdb8x7g/pdb
• Descriptor: Glucose-induced degradation protein 4 homolog, Bromodomain-containing protein 4, 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[[2-[4-[2-(1~{H}-indol-2-ylmethylamino)ethanoylamino]cyclohexyl]-3~{H}-benzimidazol-5-yl]oxy]ethoxy]ethyl]ethanamide, ... (4 entities in total)
• Functional Keywords: protac, cytosolic protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 35430.42

Authors

Dong, C.,Yan, X.,Li, Y. (deposition date: 2023-11-24, release date: 2025-03-26)

• Primary citation: Dong, C.,Yan, X.,Li, Y.; Crystal structure of 108; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)