8X7G
Crystal structure of the ternary complex of GID4-PROTAC(NEP108)-BRD4(BD1).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucose-induced degradation protein 4 homolog | polymer | 167 | 19604.8 | 1 | UniProt (Q8IVV7) Pfam (PF09783) | Homo sapiens (human) | Vacuolar import and degradation protein 24 homolog |
| 2 | B (B) | Bromodomain-containing protein 4 | polymer | 126 | 14938.2 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 3 | C (A) | 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[[2-[4-[2-(1~{H}-indol-2-ylmethylamino)ethanoylamino]cyclohexyl]-3~{H}-benzimidazol-5-yl]oxy]ethoxy]ethyl]ethanamide | non-polymer | 887.5 | 1 | Chemie (YAX) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 124 - 289 (UniProt: Q8IVV7)
B: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34542.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 887.5 | |
| All* | Total formula weight | 35430.4 |
