8WWY

Crystal structure of mouse TIFA/TIFAB heterodimer

Summary for 8WWY

Entry DOI	10.2210/pdb8wwy/pdb
Descriptor	TRAF-interacting protein with FHA domain-containing protein A, TRAF-interacting protein with FHA domain-containing protein B, (2R,5R)-hexane-2,5-diol, ... (4 entities in total)
Functional Keywords	complex, signaling protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	4
Total formula weight	67962.50
Authors	Nakamura, T. (deposition date: 2023-10-27, release date: 2024-03-13)
Primary citation	Nakamura, T.,Ohyama, C.,Sakamoto, M.,Toma, T.,Tateishi, H.,Matsuo, M.,Chirifu, M.,Ikemizu, S.,Morioka, H.,Fujita, M.,Inoue, J.I.,Yamagata, Y. TIFAB regulates the TIFA-TRAF6 signaling pathway involved in innate immunity by forming a heterodimer complex with TIFA. Proc.Natl.Acad.Sci.USA, 121:e2318794121-e2318794121, 2024 Cited by PubMed: 38442163 DOI: 10.1073/pnas.2318794121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation