8WWY

Crystal structure of mouse TIFA/TIFAB heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	TRAF-interacting protein with FHA domain-containing protein A	polymer	150	17577.1	2	UniProt (Q793I8) Pfam (PF00498)	Mus musculus (house mouse)
2	B, D (B, D)	TRAF-interacting protein with FHA domain-containing protein B	polymer	144	16167.8	2	UniProt (Q8JZM6) Pfam (PF00498)	Mus musculus (house mouse)
3	E, F, G, H (A, C, D)	(2R,5R)-hexane-2,5-diol	non-polymer		118.2	4	Chemie (HX2)
4	I, J, K, L (A, B, C, D)	water	water		18.0	475	Chemie (HOH)

Sequence modifications

A, C: 1 - 150 (UniProt: Q793I8)

PDB	External Database	Details
Ser 36	Cys 36	engineered mutation

B, D: 1 - 139 (UniProt: Q8JZM6)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	67489.8
Non-Polymers*	Number of molecules	4
	Total formula weight	472.7
All*	Total formula weight	67962.5

*Water molecules are not included.