8WSM

NLRP3 NACHT domain in complex with compound 32

Summary for 8WSM

Entry DOI	10.2210/pdb8wsm/pdb
Descriptor	NACHT, LRR and PYD domains-containing protein 3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	inflammasome, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	65056.23
Authors	Akai, S.,Orita, T.,Adachi, T. (deposition date: 2023-10-17, release date: 2023-11-22, Last modification date: 2024-01-03)
Primary citation	Ohba, Y.,Adachi, K.,Furukawa, T.,Nishimaru, T.,Sakurai, K.,Masuo, R.,Inami, T.,Orita, T.,Akai, S.,Adachi, T.,Usui, K.,Hamada, Y.,Mori, M.,Kurimoto, T.,Wakashima, T.,Akiyama, Y.,Miyazaki, S.,Noji, S. Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide. Acs Med.Chem.Lett., 14:1833-1838, 2023 Cited by PubMed: 38116417 DOI: 10.1021/acsmedchemlett.3c00433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation