8WFP
Crystal structure of polo-like kinase(PLK1)PBD in complex with DD-1
Summary for 8WFP
Entry DOI | 10.2210/pdb8wfp/pdb |
Descriptor | Serine/threonine-protein kinase PLK1, DD-1 (3 entities in total) |
Functional Keywords | inhibitor, structural protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 53422.76 |
Authors | |
Primary citation | Gunasekaran, P.,Hwang, Y.S.,Lee, G.H.,Park, J.,Kim, J.G.,La, Y.K.,Park, N.Y.,Kothandaraman, R.,Yim, M.S.,Choi, J.,Kim, H.N.,Park, I.Y.,Lee, S.J.,Kim, M.H.,Cha-Molstad, H.,Shin, S.Y.,Ryu, E.K.,Bang, J.K. Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer. J.Med.Chem., 67:3307-3320, 2024 Cited by PubMed: 38105611DOI: 10.1021/acs.jmedchem.3c01493 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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