8W2L

TRPM7 structure in complex with anticancer agent CCT128930 in closed state

8W2L の概要

• エントリーDOI: 10.2210/pdb8w2l/pdb
• EMDBエントリー: 43751
• 分子名称: Green fluorescent protein,Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ... (7 entities in total)
• 機能のキーワード: transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, cct128930
• 由来する生物種: Aequorea victoria; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 747574.04

構造登録者

Nadezhdin, K.D.,Sobolevsky, A.I. (登録日: 2024-02-20, 公開日: 2024-04-17, 最終更新日: 2024-04-24)

• 主引用文献: Nadezhdin, K.D.,Correia, L.,Shalygin, A.,Aktolun, M.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I.; Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930.; Cell Rep, 43:114108-114108, 2024; PubMed: 38615321; DOI: 10.1016/j.celrep.2024.114108

実験手法

ELECTRON MICROSCOPY (2.45 Å)