8W1L

Structure of CSF1R kinase domain in complex with Cpd 32

This is a non-PDB format compatible entry.

Summary for 8W1L

• Entry DOI: 10.2210/pdb8w1l/pdb
• Descriptor: Macrophage colony-stimulating factor 1 receptor,CSF1R, [3-({3-methoxy-4-[(6-methoxypyridin-3-yl)methoxy]phenyl}methyl)-3H-imidazo[4,5-b]pyridin-6-yl](2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone, GLYCEROL, ... (5 entities in total)
• Functional Keywords: inhibitor complex, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 38636.01

Authors

Kothe, M.,Chodaparambil, J. (deposition date: 2024-02-16, release date: 2024-05-29)

• Primary citation: Kane Jr., J.L.,Asmussen, G.,Batchelor, J.,Cromwell, M.,Fezoui, M.,Fitzgerald, M.,Giese, B.,Gladysheva, T.,Holley, S.,Keefe, K.,Kothe, M.,Lam, B.,Lim, S.,Liu, J.,Ma, L.,Metz, M.,Scholte, A.A.,Shum, P.,Wei, L.,Woodworth, L.,Edling, A.; Identification of Selective Imidazopyridine CSF1R Inhibitors.; Acs Med.Chem.Lett., 15:722-730, 2024; PubMed: 38746878; DOI: 10.1021/acsmedchemlett.4c00110

Experimental method

X-RAY DIFFRACTION (2.26 Å)