8W18
The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms
This is a non-PDB format compatible entry.
Summary for 8W18
Entry DOI | 10.2210/pdb8w18/pdb |
Descriptor | Plasma protease C1 inhibitor, Complement C1s subcomponent light chain, Complement C1s subcomponent heavy chain (3 entities in total) |
Functional Keywords | complement, c1s, c1 esterase inhibitor, michaelis complex, reactive center loop, exosite, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 88254.47 |
Authors | Garrigues, R.J.,Garcia, B.L. (deposition date: 2024-02-15, release date: 2024-06-26, Last modification date: 2024-09-11) |
Primary citation | Garrigues, R.J.,Garrison, M.P.,Garcia, B.L. The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation. J Immunol., 213:718-729, 2024 Cited by PubMed: 38995166DOI: 10.4049/jimmunol.2400194 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.94 Å) |
Structure validation
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