8W13

Crystal structure of MYST acetyltransferase domain in complex with N-(1-(5-bromo-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-2-methoxybenzenesulfonamide

This is a non-PDB format compatible entry.

Summary for 8W13

• Entry DOI: 10.2210/pdb8w13/pdb
• Descriptor: Histone acetyltransferase KAT8, N-[(1M)-1-(5-bromo-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-2-methoxybenzene-1-sulfonamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: acetyltransferase, kat8, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33855.99

Authors

Chen, C.,Dou, Y.,Wang, M.,Xu, C.,Buesking, A. (deposition date: 2024-02-15, release date: 2024-09-11)

• Primary citation: Chen, C.,Pawley, S.B.,Cote, J.,Carter, J.,Wang, M.,Xu, C.,Buesking, A.W.; Identification of triazolyl KAT6 inhibitors via a templated fragment approach; Bioorg.Med.Chem.Lett., :129948-, 2024; DOI: 10.1016/j.bmcl.2024.129948

Experimental method

X-RAY DIFFRACTION (1.81 Å)