8W13
Crystal structure of MYST acetyltransferase domain in complex with N-(1-(5-bromo-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-2-methoxybenzenesulfonamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase KAT8 | polymer | 278 | 32544.5 | 1 | UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) | Homo sapiens (human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,MYST-1,hMOF |
| 2 | B (A) | N-[(1M)-1-(5-bromo-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-2-methoxybenzene-1-sulfonamide | non-polymer | 439.3 | 1 | Chemie (A1AEW) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 4 | L, M, N, O, P... (A) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 5 | S (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | T (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 174 - 449 (UniProt: Q9H7Z6)
| PDB | External Database | Details |
|---|---|---|
| Gly 172 | - | expression tag |
| Ser 173 | - | expression tag |
| His 249 | Tyr 249 | conflict |
| Ser 315 | Ala 315 | conflict |
| Met 318 | Leu 318 | conflict |
| Ile 319 | Thr 319 | conflict |
| Arg 330 | Lys 330 | conflict |
| Ser 367 | Trp 367 | conflict |
| Asn 372 | Ile 372 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32544.5 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1311.5 | |
| All* | Total formula weight | 33856.0 |
