8VUI
Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor
Summary for 8VUI
Entry DOI | 10.2210/pdb8vui/pdb |
Related | 8VTP 8VTR 8VU1 8VU4 8VUA 8VUC |
Descriptor | S1CE VARIANT OF FAB-EPR-1 heavy chain, S1CE VARIANT OF FAB-EPR-1 light chain, Erythropoietin receptor, ... (10 entities in total) |
Functional Keywords | proliferation, engineered antibody, high-affinity binding, enhanced crystallization, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 73712.30 |
Authors | Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sidhu, S.S. (deposition date: 2024-01-29, release date: 2024-07-10) |
Primary citation | Bruce, H.A.,Singer, A.U.,Blazer, L.L.,Luu, K.,Ploder, L.,Pavlenco, A.,Kurinov, I.,Adams, J.J.,Sidhu, S.S. Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33:e5081-e5081, 2024 Cited by PubMed: 38924648DOI: 10.1002/pro.5081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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