8VU9

Crystal structure of wild-type HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 5i3

Summary for 8VU9

• Entry DOI: 10.2210/pdb8vu9/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, (2E)-3-[4-({2-[(1-{[4-(methanesulfonyl)phenyl]methyl}piperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-4-yl}oxy)-3,5-dimethylphenyl]prop-2-enenitrile, ... (7 entities in total)
• Functional Keywords: non-nucleoside reverse transcriptase inhibitor, transferase, transferase-transferase inhibitor complex, viral protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Human immunodeficiency virus type 1 BH10; More
• Total number of polymer chains: 2
• Total formula weight: 115451.38

Authors

Rumrill, S.,Ruiz, F.X.,Arnold, E. (deposition date: 2024-01-29, release date: 2025-05-07, Last modification date: 2025-05-28)

• Primary citation: Wang, Z.,Rumrill, S.R.,Kang, D.,Desta, S.,Feng, D.,De Clercq, E.,Pannecouque, C.,Chen, C.H.,Arnold, E.,Ruiz, F.X.,Liu, X.,Zhan, P.; Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.99 Å)