8VTC

Crystal structure of Mycobacterium avium dihydrofolate reductase in complex with NADPH and trimethoprim

Summary for 8VTC

• Entry DOI: 10.2210/pdb8vtc/pdb
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... (5 entities in total)
• Functional Keywords: dihydrofolate reductase, mycobacterium avium, trimetoprim, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium avium
• Total number of polymer chains: 1
• Total formula weight: 19523.01

Authors

Erlandsen, H.,Krucinska, J.,Wright, D. (deposition date: 2024-01-26, release date: 2025-03-19)

• Primary citation: Wright, L.,Krucinska, J.,Erlandsen, H.,Haijan, B.,Cynamon, M.,Wright, D.; Long Residence Time Inhibitors of Dihydrofolate Reductase Display Potent Activity Against Mycobacterium Avium.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)