8VRS

Mucin 16 peptide fused to MBP in complex with 4H11-scFv antibody

8VRS の概要

• エントリーDOI: 10.2210/pdb8vrs/pdb
• 関連するPDBエントリー: 8VRR
• 分子名称: Maltose/maltodextrin-binding periplasmic protein,Mucin-16, 4H11 scFv chain (3 entities in total)
• 機能のキーワード: antibody complex epitope cancer therapy immunotherapy mucins, oncoprotein, oncoprotein-immune system complex, oncoprotein/immune system
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 142226.87

構造登録者

Lee, K.,Perry, K.,Yeku, O.O.,Spriggs, D.R. (登録日: 2024-01-22, 公開日: 2024-04-03, 最終更新日: 2024-11-06)

主引用文献

Lee, K.,Perry, K.,Xu, M.,Veillard, I.,Kumar, R.,Rao, T.D.,Rueda, B.R.,Spriggs, D.R.,Yeku, O.O.
Structural basis for antibody recognition of the proximal MUC16 ectodomain.
J Ovarian Res, 17:41-41, 2024

PubMed Abstract: Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodular fragments, the shed tandem repeat sequence which circulates as a protein bearing the ovarian cancer biomarker (CA125) and a proximal membrane-bound component which is critical in MUC16 oncogenic behavior. A humanized, high affinity antibody targeting the proximal ectodomain represents a potential therapeutic agent against MUC16 with lower antigenic potential and restricted human tissue expression.

PubMed: 38374055
DOI: 10.1186/s13048-024-01373-9

実験手法

X-RAY DIFFRACTION (2.47 Å)