8VRR

4H11-scFv antibody

Summary for 8VRR

• Entry DOI: 10.2210/pdb8vrr/pdb
• Related: 8VRS
• Descriptor: 4H11 scFv chain (2 entities in total)
• Functional Keywords: single-chain antibody humanized nanobody, peptide binding protein, immune system
• Biological source: Mus musculus
• Total number of polymer chains: 1
• Total formula weight: 27449.22

Authors

Lee, K.,Perry, K.,Yeku, O.O.,Spriggs, D.R. (deposition date: 2024-01-22, release date: 2024-04-03, Last modification date: 2024-11-13)

Primary citation

Lee, K.,Perry, K.,Xu, M.,Veillard, I.,Kumar, R.,Rao, T.D.,Rueda, B.R.,Spriggs, D.R.,Yeku, O.O.
Structural basis for antibody recognition of the proximal MUC16 ectodomain.
J Ovarian Res, 17:41-41, 2024

PubMed Abstract: Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodular fragments, the shed tandem repeat sequence which circulates as a protein bearing the ovarian cancer biomarker (CA125) and a proximal membrane-bound component which is critical in MUC16 oncogenic behavior. A humanized, high affinity antibody targeting the proximal ectodomain represents a potential therapeutic agent against MUC16 with lower antigenic potential and restricted human tissue expression.

PubMed: 38374055
DOI: 10.1186/s13048-024-01373-9

Experimental method

X-RAY DIFFRACTION (2.36 Å)