8VKA

Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 9c

This is a non-PDB format compatible entry.

Summary for 8VKA

• Entry DOI: 10.2210/pdb8vka/pdb
• Descriptor: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, N-[1,5-dimethyl-4-(2-{[(2M)-2'-(piperazin-1-yl)[2,4'-bipyridin]-3-yl]oxy}ethyl)-1H-pyrazole-3-carbonyl]glycine, ... (9 entities in total)
• Functional Keywords: enzyme, inhibitor, complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase
• Biological source: Plasmodium vivax Sal-1
• Total number of polymer chains: 3
• Total formula weight: 141628.36

Authors

Fenwick, M.K.,Staker, B.L.,Phan, I.Q.,Early, J.,Myler, P.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2024-01-08, release date: 2024-07-17)

• Primary citation: Rodriguez-Hernandez, D.,Fenwick, M.K.,Zigweid, R.,Sankaran, B.,Myler, P.J.,Sunnerhagen, P.,Kaushansky, A.,Staker, B.L.,Grotli, M.; Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors.; J.Med.Chem., 67:7312-7329, 2024; PubMed: 38680035; DOI: 10.1021/acs.jmedchem.4c00168

Experimental method

X-RAY DIFFRACTION (1.97 Å)