8VHR

Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP

Summary for 8VHR

Entry DOI	10.2210/pdb8vhr/pdb
Related	8VHN 8VHO 8VHP 8VHQ 8VHU
Descriptor	Ribonucleoside-diphosphate reductase 1 subunit alpha, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit interaction, oxidoreductase
Biological source	Escherichia coli K-12
Total number of polymer chains	4
Total formula weight	356944.65
Authors	Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (deposition date: 2024-01-02, release date: 2024-09-04)
Primary citation	Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L. How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase. Biochemistry, 2024 Cited by PubMed: 39164005 DOI: 10.1021/acs.biochem.4c00329 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.55 Å)

Structure validation