8VHP
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP
Summary for 8VHP
Entry DOI | 10.2210/pdb8vhp/pdb |
Related | 8VHN 8VHO 8VHQ 8VHR 8VHU |
Descriptor | Ribonucleoside-diphosphate reductase 1 subunit alpha, SULFATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit interaction, oxidoreductase |
Biological source | Escherichia coli K-12 |
Total number of polymer chains | 8 |
Total formula weight | 721085.22 |
Authors | Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (deposition date: 2024-01-02, release date: 2024-09-04, Last modification date: 2024-10-09) |
Primary citation | Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L. How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase. Biochemistry, 63:2517-2531, 2024 Cited by PubMed: 39164005DOI: 10.1021/acs.biochem.4c00329 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.608 Å) |
Structure validation
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