8VHN

Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to two ATP molecules

Summary for 8VHN

Entry DOI	10.2210/pdb8vhn/pdb
Related	8VHO 8VHP 8VHQ 8VHR 8VHU
Descriptor	Ribonucleoside-diphosphate reductase 1 subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit, oxidoreductase
Biological source	Escherichia coli K-12
Total number of polymer chains	2
Total formula weight	175469.14
Authors	Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (deposition date: 2024-01-02, release date: 2024-09-04, Last modification date: 2024-10-09)
Primary citation	Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L. How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase. Biochemistry, 63:2517-2531, 2024 Cited by PubMed: 39164005 DOI: 10.1021/acs.biochem.4c00329 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation