8V58

Complex of murine cathepsin K with bound heparan sulfate 12mer

Summary for 8V58

• Entry DOI: 10.2210/pdb8v58/pdb
• Descriptor: Cathepsin K, beta-D-galactopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (6 entities in total)
• Functional Keywords: complex, heparan sulfate, protease, collagenase, hydrolase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 51638.97

Authors

Pedersen, L.C.,Xu, D.,Krahn, J.M. (deposition date: 2023-11-30, release date: 2024-10-09)

• Primary citation: Zhang, X.,Luo, Y.,Hao, H.,Krahn, J.M.,Su, G.,Dutcher, R.,Xu, Y.,Liu, J.,Pedersen, L.C.,Xu, D.; Heparan sulfate selectively inhibits the collagenase activity of cathepsin K.; Matrix Biol., 129:15-28, 2024; PubMed: 38548090; DOI: 10.1016/j.matbio.2024.03.005

Experimental method

X-RAY DIFFRACTION (3.1 Å)