8V3N

CCP5 in complex with Glu-P-Glu transition state analog

This is a non-PDB format compatible entry.

Summary for 8V3N

• Entry DOI: 10.2210/pdb8v3n/pdb
• Descriptor: Cytosolic carboxypeptidase-like protein 5, ZINC ION, D-MALATE, ... (5 entities in total)
• Functional Keywords: carboxypeptidase deglutamylation branch glutamate removal microtubule, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 59884.58

Authors

Chen, J.,Zehr, E.A.,Gruschus, J.M.,Szyk, A.,Liu, Y.,Tanner, M.E.,Tjandra, N.,Roll-Mecak, A. (deposition date: 2023-11-28, release date: 2024-07-17, Last modification date: 2024-08-07)

• Primary citation: Chen, J.,Zehr, E.A.,Gruschus, J.M.,Szyk, A.,Liu, Y.,Tanner, M.E.,Tjandra, N.,Roll-Mecak, A.; Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.; Nature, 631:905-912, 2024; PubMed: 39020174; DOI: 10.1038/s41586-024-07699-0

Experimental method

X-RAY DIFFRACTION (2.3 Å)