8UWC

Site-one protease without SPRING

8UWC の概要

• エントリーDOI: 10.2210/pdb8uwc/pdb
• EMDBエントリー: 42661
• 分子名称: Membrane-bound transcription factor site-1 protease, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: serine protease cholesterol metabolism zymogen activation protein complex glycoprotein secretory pathway, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 114105.00

構造登録者

Kober, D.L. (登録日: 2023-11-06, 公開日: 2024-07-10, 最終更新日: 2024-07-24)

• 主引用文献: Hendrix, S.,Dartigue, V.,Hall, H.,Bawaria, S.,Kingma, J.,Bajaj, B.,Zelcer, N.,Kober, D.L.; SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain.; Nat Commun, 15:5732-5732, 2024; PubMed: 38977690; DOI: 10.1038/s41467-024-50068-8

実験手法

ELECTRON MICROSCOPY (2.27 Å)